Resources
Tools and references for compound form factor decisions.
Technical guides, material specifications, and reference material to help you specify the right geometry for your application - before you place an order.
Technical guides, material specifications, and reference material to help you specify the right geometry for your application - before you place an order.
Whether you're casting ten grams of a novel API for preclinical work or running quarterly production of a specialty reagent, the geometry requirement is the same - and so is our tolerance.
Novel drug candidates, lead compounds, and active pharmaceutical ingredients needing a reproducible form factor for preclinical studies. Small-batch prototype runs, no minimum order.
Solid dosage form production, soft gel capsule tooling, controlled-release pellet molds, and lyophilization trays for commercial and clinical-stage drug programs. Full regulatory documentation supplied.
Calibration standards, immunoassay reagent matrices, synthesized reference compounds, and specialty chemical concentrates requiring dimensional reproducibility across production lots.
Casting molds for hydrogels, polymer matrices, tissue engineering scaffolds, and bioinks. Shape and pore geometry in these materials directly determines mechanical properties and cell behavior.
Implantable drug depots, microsphere suspensions, transdermal patch matrices, and mucoadhesive forms. We work with formulation scientists to match mold geometry to target release kinetics.
Organoid culture substrates, micro-well tissue culture arrays, viral vector production trays, lipid nanoparticle casting molds, and cell aggregate forms for GMP-adjacent manufacturing environments.
Silicone is our core material, but every job gets matched to the right substrate. Grade tables and specs for everything we fabricate in.
Short, practical references written for scientists - not engineers. Each covers one decision point in the mold specification process.
Why surface area to volume ratio is the single most predictive geometric parameter for dissolution rate, and how to calculate it for hemisphere, channel, lentil, hex, and cube-well arrays.
Request PDFA decision framework for mold material selection based on compound chemistry, casting temperature, solvent contact, regulatory requirements, and production volume.
Request PDFWorked examples showing the relationship between cavity volume tolerance and unit-to-unit mass variance - critical for potent compounds and limited-supply intermediates.
Request PDFComparative dissolution profiles for the five core array geometries - hemisphere, channel, lentil, hex, and cube-well. Includes the governing equations and practical guidelines for matching cavity form to target T₅₀ and T₈₀ release windows.
Request PDFA walkthrough of the information required for a DFM review - from CAD formats and dimensional callouts to compound class, casting method, and downstream process constraints.
Request PDFWe write technical reference material on request. If there's a form factor question your team keeps running into, let us know.
Request a Guide →Definitions focused on what these terms mean for mold geometry decisions.
Governing dissolution equation: mass transfer rate is proportional to surface area and concentration gradient.
Dissolution rate per unit surface area under sink conditions. A compound property, independent of geometry.
Cube-root relationship between mass and surface area as a tablet erodes uniformly from all faces.
Stagnant solvent film at the dissolving surface. Agitation thins it and speeds dissolution. Typically 10–100 µm.
Dissolved concentration stays well below saturation (C < 0.2 × Cs), keeping the driving gradient near-constant.
Surface area ÷ volume - the top geometric predictor of dissolution rate. Thinner, smaller parts dissolve faster.
Time to 50/80/90% dissolution. T₈₀ is a common benchmark; T₉₀ marks near-complete dissolution. Outputs, not inputs.
Diffusion coefficient in the solvent. Depends on molecular size, viscosity, temperature. ~0.5–2.0 × 10⁻⁹ m²/s in water at 25°C.
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